Momoko Yoshimoto's Lab has moved to
Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan!
Our Projects
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The developmental pathways of fetal-derived B cells
Our recent data indicate that not only innate-like B-1a cells but also a port of adaptive immune B-2 cells are derived from endothelial cells independently of HSCs. We utilize lineage tracing and barcoding mouse models to determine the developmental pathways of these B cells.
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Hematopoietic Stem Cell Development
We are trying to understand the molecular mechanisms through which the first HSCs are produced from hemogenic endothelial cells in the mouse embryos, using various lineage tracing mouse models, transplantation assays, and single-cell RNA-sequencing
The different roles of fetal-derived and HSC-derived lymphocytes
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Our lineage tracing study revealed that there are fetal-derived and HSC-derived lymphocytes in adult mice. We will determine the different functions between these lymphocyte subsets.
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